loader image

A POTENT GnRH AGONIST

Trelstar is a gonadotropin-releasing hormone (GnRH) agonist that differs from natural GnRH by a single amino acid.1 , 2

Trelstar has been engineered to deliver superagonist activity.3,4

  • Trelstar is a synthetic decapeptide analog of GnRH2
  • Trelstar differs from natural GnRH by a single amino acid substitution at position 62
  • In animal studies, Trelstar was found to have 13-fold higher luteinizing hormone-releasing activity and 21-fold higher follicle-stimulating hormone-releasing activity compared to natural GnRH1
  • 1 modified amino acid vs. 2 for leuprolide and goserelin7
  • High affinity in vitro for the LHRH receptor in the pituitary gland (6 x higher vs. leuprolide)7

In vitro studies. The clinical significance of this information is unknown.

LongER Half-Life 7,9
IncreaseD Receptor-Binding Affinity 7
Low Potential for Enzyme Cleavage 2,7
High Biologic ACTIVITY 7
131 TIMES MORE ACTIVE THAN NATIVE GnRH 2,7

Comparative Structure of GnRH Agonists: Amino Acid Sequences 8

  • The clinical significance of this information is unknown. Information is not to imply comparative efficacy/safety between the products; no head-to-head clinical trials have been conducted to compare the products.

Order Trelstar from CuraScriptSD®

Trelstar can be ordered directly from our national specialty distributor, CuraScriptSD®, which provides next business day delivery and other convenient benefits. Call CuraScriptSD® at 877.599.7748.

If you already have a Trelstar account with CuraScriptSD®, please click here or register at www.curascriptsd.com.

Order Trelstar from AndaMEDS®

Trelstar can be ordered directly from our national specialty distributor, AndaMEDS, which provides next business day delivery and other convenient benefits. Call AndaMEDS at 1.855.468.5649, ext.74453.

If you already have a Trelstar account with AndaMEDS®, please click here or register at www.andameds.com.

Thank you for visiting.

You are now leaving a Verity website. A link to a non-Verity website does not constitute an endorsement of the products or services offered by the non-Verity website, and Verity is not responsible for the content of any non-Verity website.

Healthcare Professionals

The information contained in this website is intended for US Healthcare professionals only.