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A POTENT GnRH AGONIST

Trelstar is a gonadotropin-releasing hormone (GnRH) agonist that differs from natural GnRH by a single amino acid.1 , 2

Trelstar has been engineered to deliver superagonist activity.3,4

  • Trelstar is a synthetic decapeptide analog of GnRH2
  • Trelstar differs from natural GnRH by a single amino acid substitution at position 62
  • In animal studies, Trelstar was found to have 13-fold higher luteinizing hormone-releasing activity and 21-fold higher follicle-stimulating hormone-releasing activity compared to natural GnRH1
  • 1 modified amino acid vs. 2 for leuprolide and goserelin7
  • High affinity in vitro for the LHRH receptor in the pituitary gland (6 x higher vs. leuprolide)7

In vitro studies. The clinical significance of this information is unknown.

LongER Half-Life 7,9
IncreaseD Receptor-Binding Affinity 7
Low Potential for Enzyme Cleavage 2,7
High Biologic ACTIVITY 7
131 TIMES MORE ACTIVE THAN NATIVE GnRH 2,7

Comparative Structure of GnRH Agonists: Amino Acid Sequences 8

  • The clinical significance of this information is unknown. Information is not to imply comparative efficacy/safety between the products; no head-to-head clinical trials have been conducted to compare the products.

Order Trelstar from AndaMEDS

Trelstar can be ordered directly from our national specialty distributor, AndaMEDS, which provides next business day delivery and other convenient benefits. Call AndaMEDS at 1.855.468.5649, ext.74453.

 

If you already have a Trelstar account with AndaMEDS®, please click here or register at www.andameds.com.

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